Developmental Endothelial Locus-1 (Del-1), a Novel Angiogenic Protein
نویسندگان
چکیده
منابع مشابه
Developmental endothelial locus-1 (Del-1), a novel angiogenic protein: its role in ischemia.
BACKGROUND Developmentally regulated endothelial locus-1 (Del-1) is an extracellular matrix protein that is expressed by endothelial cells during embryological vascular development. We speculated that Del-1 may be reexpressed in ischemia and may be involved in endogenous angiogenesis. METHODS AND RESULTS Del-1 protein was detected by immunohistochemistry in murine ischemic hindlimb after femo...
متن کاملDevelopmental Endothelial Locus – 1 ( Del - 1 ) Mediates Clearance of Platelet Microparticles by the Endothelium Running title :
Background-Phosphatidylserine-expressing microparticles circulate in blood with a short half
متن کاملDevelopmental endothelial locus-1 (Del-1) mediates clearance of platelet microparticles by the endothelium.
BACKGROUND Phosphatidylserine-expressing microparticles circulate in blood with a short half-life of <10 minutes. We tested the role of an endothelium-derived phosphatidylserine-binding opsonin, developmental endothelial locus-1 (Del-1), in the uptake of platelet microparticles. METHODS AND RESULTS Cultured human umbilical vein and microvascular endothelial cells avidly engulf BODIPY (4,4-dif...
متن کاملInhibition of Leukocyte Adhesion by Developmental Endothelial Locus-1 (Del-1)
The leukocyte adhesion to endothelium is pivotal in leukocyte recruitment which takes place during inflammatory, autoimmune and infectious conditions. The interaction between leukocytes and endothelium requires an array of adhesion molecules expressed on leukocytes and endothelial cells, thereby promoting leukocyte recruitment into sites of inflammation and tissue injury. Intervention with the ...
متن کاملVascular Medicine Developmental Endothelial Locus-1 (Del-1) Mediates Clearance of Platelet Microparticles by the Endothelium
Background—Phosphatidylserine-expressing microparticles circulate in blood with a short half-life of 10 minutes. We tested the role of an endothelium-derived phosphatidylserine-binding opsonin, developmental endothelial locus-1 (Del-1), in the uptake of platelet microparticles. Methods and Results—Cultured human umbilical vein and microvascular endothelial cells avidly engulf BODIPY (4,4-difluo...
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ژورنال
عنوان ژورنال: Circulation
سال: 2004
ISSN: 0009-7322,1524-4539
DOI: 10.1161/01.cir.0000118465.36018.2d